Russia — ALLIANCE FOR THE PRUDENT USE OF ANTIBIOTICS

APUA Russian Chapter Update 2020

APUA Russia was established by The Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy (IACMAC) that was founded in 1997 through collaborative links amongst microbiologists from different Russian cities which have been established previously when the first multicenter microbiological studies were carried out. Now, IACMAC includes over 1,300 members from 48
regions of the Russia.

Collaboration with international societies
Russian chapter of APUA closely collaborates with the following societies and organisations:
European Society for Clinical Microbiology and Infectious Diseases (ESCMID)
British Society for Antimicrobial Chemotherapy (BSAC)
International Society of Antimicrobial Chemotherapy (ISAC) and The Alliance for the Prudent Use of Antibiotics (APUA)
World Health Organization (WHO)
American Society for Microbiology (ASM)
Western Pacific Society of Chemotherapy

Antibiotic resistance monitoring

Russian chapter of APUA is involved in establishment of programs of interregional antibiotic resistance monitoring (RosNet) and development of plans for expansion of the programs onto national level. Institute of Antimicrobial Chemotherapy (IAC) at the Smolensk State Medical University (SSMU)-based reference laboratory provides data for the numerous multicenter studies under IACMAC supervision.
Collaboration in clinical and microbiological multicenter studies:
     Spread and resistance research of RTI, UTI, bloodstream and surgical
     infections of hospital (including ICU) and community-acquired pathogens.
     The new studies and phases of ongoing studies for 2020 includes PeHASus -
     Antibiotic resistance surveillance of the main pathogens causing upper RTIs (S. pneumoniae, H. influenzae, S. pyogenes), MARATHON -
     Multicenter surveillance study on antimicrobial resistance of nosocomial
     pathogens, SPECTRUM - an Epidemiological, Microbiological survey to
     establish the spectrum of Circulating seroTypes of S. pneumoniae, in patients older 18 years: healthy Carriage,
     patients with non-invasive and invasive pneumococcal infections in Russian
     Federation)
Russian National Guidelines for Antimicrobial Resistance Testing are now harmonized with current 2018 EUCAST Guidelines and
available on Russian on the IACMAC web site.
IACMAC conferences have been certified for credits of continuous medical education for microbiologists and clinicians.
Introduced in 2017 Map of Antimicrobial Resistance of Russia, an interactive system for monitoring antibiotic resistance, with set of tools for analysing and visualising data on the susceptibility of microorganisms to antibiotics. Susceptibility data for new pathogens and antibiotics updated in 2019.

Congresses & Meetings
Annually, APUA Russia, together with IACMAC, organises International Congress on Antimicrobial Therapy in Moscow (each May) in collaboration with APUA and ESCMID, followed by 2 regional conferences in different parts of Russia. Over the 2019 the following conferences were held

XXI International Congresses on Antimicrobial Therapy (Moscow) – 1253 participants
Conference in Krasnodar (28-29 March 2019) and International Congress in Ufa (17-18
October 2019) – total 2757 participants

Planned activities:

XXII International Congresses on Antimicrobial Therapy in Moscow (21-23 May 2020)
Regional conferences in Nizhny Novgorod (19-20 March 2020) and Belgorod (15-16 October
2020)

Additional education activity includes:

Graduate educational courses on bacteriology and clinical pharmacology for bacteriologists and clinicians
The first internet center of distance education on antimicrobial chemotherapy in Russia
All-Russian educational project «Diagnosis, treatment, prevention of infections caused by multi-resistant microorganisms

Publications

The Russian chapter of APUA is involved together with IACMAC in publication of journals, reference materials, practice guides, national clinical guidelines on the treatment and management of infectious diseases, and provides an informational support for the IACMAC members.

2019 Update

Together with The Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy (IACMAC), APUA Russia has:

• Established programmes for interregional / national AMR monitoring (RosNet).

• Developed Russian National Guidelines for AMR testing and harmonised with EUCAST Guidelines

• 2017 - 2019: held 2 International Congresses and 5 regional conferences on antimicrobial therapy. Planned activities:

• XXI International Congresses on Antimicrobial Therapy in Moscow (22-24 May 2019)

• Russian-Chinese Congress on Antimicrobial Therapy (17-18 Oct 2019) Additional education activity includes

• Graduate educational courses on bacteriology and clinical pharmacology for bacteriologists and clinicians

• The first internet centre of distance education on antimicrobial chemotherapy in Russia

• All-Russian educational project “Diagnosis, treatment, prevention of infections caused by MDR microorganisms”

STATUS OF ANTIBIOTIC RESISTANCE

Antibiotic resistance problems of major concern in Russia include the spread of multidrug resistant ESBL-producing organisms and MRSA. One of the causes of resistance problems identified by chapter members is the lack of regulation of antibiotic use in agriculture. These problems lead to challenges in treating infectious diseases that are prevalent in the country, such as acute respiratory infections.

CHAPTER OVERVIEW

APUA Russia was established in 1997 and since then, it has assisted in the development of other APUA chapters within the Eastern European region. Chapter members frequently participate in national and international conferences and symposiums.

Chapter Objectives and Priorities:

Establish and strengthen systems of surveillance of antibiotic use and resistance
Development of guidelines for curbing resistance
Promote the prudent use of antibiotics
Organize conferences and symposia
Support national and international research in the field of antimicrobial chemotherapy
Publish research results on antibiotic use and antibiotic resistance
Publish and distribute the APUA Newsletter in Russian.

CHAPTER ACTIVITIES

Funded through the APUA Small Grants Program, APUA Russia conducted a study on "Cost-effectiveness analysis of miniVITAL automated system vs. routine microbiological procedures for blood cultures from ICU patients with sepsis."

The APUA Small Grants program also funded a study called, "The Inventory of Antibiotics in Russian Home Medicine Cabinets," conducted by L. S. Stratchounski, a professor at the Department of Clinical Pharmacology at Smolensk State Medical Academy. The survey revealed that most Russian families possess antibiotics for systemic use at home and would use them without a doctor's prescription. This study served as the basis of a public information strategy aimed at promoting the prudent use of antibiotics.

The APUA Russia chapter has translated and published a Russian edition of the APUA Newsletter that was distributed to several APUA chapters in Eastern and Central Europe.

Chapter members are involved in a national surveillance program tracking data on antibiotic use, patient information and resistance patterns. Data collected from 35 regional laboratories are compiled in a central laboratory.

Read 2014 chapter updates here

CHAPTER LEADERSHIP

Roman S. Kozlov
Andrey V. Dekhnitch
Anatoly Nikulin

PUBLICATIONS

Educational web project, "Map of Resistance" (http://www.antibiotic.ru/)
Summarizes published data on antimicrobial resistance of main bacterial pathogens causing community-acquired and nosocomial infections. The aim of this project is to provide free access to information about antimicrobial resistance in every region of Russia for specialists. Map of antimicrobial resistance of Russia includes results of the studies carried out by Institute of Antimicrobial Chemotherapy (IAC), Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy (IACMAC), Scientific Center of Monitoring Antimicrobial Resistance of the Federal Agency of Health and Social Development (SCMAR). All data are constantly updated as new results of surveys are published.

Internet Center of Distance Education on Antimicrobial Chemotherapy in Russia (http://www.antibiotic.ru/en/re/). For the time being, more than 350 physicians from different regions of Russia and other countries have successfully completed the course. This course is officially recognized by MoH.

Publication of the 3rd edition of "Practical guideline on antiinfectious chemotherapy," together with US Pharmacopoeia (editors Stratchounski L.S., Belousov Yu.B., Kozlov S.N.), 2007, 464. 20,000 copies issued. The guideline is distributed among doctors free of charge.

Publication of "Guideline on antimicrobial therapy" (editor Stratchounski L.S.), 2006, 384. 20,000 copies issued. The guideline is distributed among doctors free of charge.

"Current clinical recommendations on antimicrobial therapy" (Issue 1 -2004, 384 p., 5,000 copies issued; Issue 2 - 2007, 608 p., 2,000 copies issued)