News: Antibiotic Resistance in the News
December 21, 2010
House Passes Food Safety Bill
December 21, 2010
Pew: Approval of Landmark Legislation Will Limit Dangers in the U.S Food Supply
December 20, 2010
FDA Reveals How Many Antibiotics Factory Farms Really Use
December 17, 2010
CDC Issues 2010 Treatment Guidelines for Sexually Transmitted Diseases
December 13, 2010
FDA Releases First Estimate on Antibiotics in Agriculture-29 million pounds!
November 24, 2010
Dr. Anthony Fauci, NIAID Director, speaks about increasing number of antibiotic resistant diseases; Congressman Phil Gingrey discusses his legislation to increase the number of antibiotics in the pipeline - C-SPAN
November 5, 2010
Antibiotics Research Subsidies Weighed by U.S.
November 4, 2010
Common Antibacterial Agent Could Cause Pregnancy Issues
October 16, 2010
Sequencing of superbugs seen as key to combating their spread- Nature Medicine Journal article
October 7, 2010
MRSA hits lobstermen in Maine
October 6, 2010
FDA strengthens its focus on antibiotic resistance
August 11, 2010
Scientists find new superbug spreading from India
June 14, 2010
A new report, The Race Against Drug Resistance, from the Center for Global Development says there is a need for urgent action to tackle the growing crisis of drug resistance.
April 14, 2010
Keep Antibiotics Working, IDSA, APHA, The Pew Charitable Trusts, UCS sponsor Capital Hill Briefings titled "Antibiotic Use on the Farm and Public Health: A Looming Crisis."
April 1, 2010
Interagency Action Plan Public Comment from APUA
March 15, 2010
Outwitting germs that never say die
Duets beyond music: tackling the flu, seasonal and pandemic vaccines
February 12, 2010
Cost of Antibiotic Resistance Shifting from Public to Private Payers
January 25, 2010
APUA Letter to Rep. Markey RE: triclosan
January 20, 2010
WebMD: Relapses in C. diff infections reduced
January 19, 2010
Infection follows disaster in Haiti
August 11, 2008
Superbugs by Jerome Groopman
August 11, 2008
Editorial Commentary: Antibiotics for Treatment of Acute Respiratory Tract Infections: Decreasing Benefit, Increasing Risk, and the Irrelevance of Antimicrobial Resistance
February 12, 2008
Resistant Meningitis Strain Found
January 8, 2008
Will Antibiotics Beat a Sinus Infection?
November 20, 2007
Scientists Decode Genes of Resistant TB
October 30, 2007
Germ Fighters May Lead to Hardier Germs
October 23, 2007
Bad Bugs, Few Drugs
October 17, 2007
Resistant Hospital Acquired Infections Growing
September 23, 2007
Threat From the New E. coli
September 13, 2007
CA-MRSA The New Sports Pathogen
August 24, 2007
Fighting Superbugs- Congressional Quarterly
Oct 9, 2007
A CIPARS study provided data to stakeholders leading to a voluntary withdrawal in Québec chicken hatcheries of the extra-label use of ceftiofur
June 17, 2007
Antibiotics in Failing Health
June 13, 2007
Cefquinome: When Regulation Collides With Biology
June 5, 2007
Specialists to Say Drug-Resistant TB to Occur More
March 20, 2007
Hold the Pickles and the Penicillin: Leading Food-Service Company to Serve Antibiotic Free Hamburgers Nationwide
March 20, 2007
Bon Appetit Management Co. Stays Ahead of the Curve, Naturally
March 20, 2007
Rise of Deadly TB Reveals a Global System in Crisis
March 6, 2007
New Antibiotic Now Available to Battle MRSa in Canadian Hospitals
March 4, 2007
FDA Rules Override Warnings About Drug
March 4, 2007
Household Antibacterial Products Can Be Dangerous
February 27, 2007
Majority of South Africans with HIV Have Drug-Resistant TB
February 25, 2007
Hospitals' Hidden Danger
February 21, 2007
Transmitted TB Resistance High in Shanghai
February 8, 2007
Doctors Say Superbug Battle is Winnable
February 8, 2007
Antibiotic Overuse Does Make Microbes Resistant
February 6, 2007
Anti-MRSA Pajamas Trialled
January 27, 2007
Virulent TB in South Africa May Imperil Millions
January 23, 2007
New Drug-Resistant Tuberculosis Cases Appearing in South Africa
January 18, 2007
Staph Toxin Can Trigger Deadly Pneumonia
January 15, 2007
Researchers Discover Surprising Drug that Blocks Malaria
November 27, 2006
Antibiotic Indulgence: Misuse of a Miracle
November 25, 2006
The Arms Race in Hand Soap Leads to Serious Overkill
November 20, 2006
One Preop Antibiotic is as Good as Several Postop
November 20, 2006
Skip the Antibacterial Soap
November 19, 2006
New Treatment Uses Human Antibodies to Target C. difficile Toxins
November 14, 2006
To Catch a Deadly Germ
November 14, 2006
HIV/AIDS Linked to Extensive Drug Resistant TB
November 7, 2006
Most Ear Infections Host Both Bacteria and Viruses
October 31, 2006
Superbug Vaccine Shows Promise
October 24, 2006
Why Isn't the US Killing Off More Hospital Infections?
October 23, 2006
Antibiotic Resistance Genes Found in Colorado River Water
October 18, 2006
Deadly XDR-TB Found in All Nine Provinces of South Africa
October 14, 2006
Increased Levels of Antibiotic Resistance in Gonorrhea, UK
October 13, 2006
Antibiotics in Poultry May Pose Risk to Humans
September 26, 2006
Utilizing a Natural Enemy to Kill E. coli
August 28, 2006
Scientists Find Anthrax 'Blocker'
August 29, 2006
Protein Structure Reveals New Antibiotic Treatment
August 24, 2006
Sick of Getting Sick? Embrace Your Inner Bacteria
August 21, 2006
Skin Scourge- Boston Globe
August 19, 2006
Study Finds MRSA Most Common Cause of Skin Infections in US ERs
August 19, 2006
Staph Infection Outbreak in Duluth Prison
August 7, 2006
UK Grants Support Antibiotic Resistance Research
August 3, 2006
Washington Redskins Take Precautions Against MRSA
August 2, 2006
Pittsburgh VA Cracking Down on MRSA
August 1, 2006
Resistant Hospital Acquired Pneumonia Doubly Lethal
July 24, 2006
Inadequate Hospital hand Hygiene is Spreading MRSA
July 11, 2006
Bulky Biofilms Found in Kid's Ears
July 10, 2006
Performance Measures May Lead to Overuse of Antibiotics
July 2, 2006
Seafloor as Potential Source of New Antibiotics
June 23, 2006
MRSA Infections Have Been Linked to Illegal Tattoos
April 18, 2006
Fishtanks: A Reservoir of Multi Drug Resistant Salmonella
March 14, 2006
Baby Antibiotics 'Link to Asthma'
Drug-resistant Acinetobacter baumannii bacterial infections rising in American military
August 4, 2005
Health providers have detected unexpectedly high rates of infection by drug-resistantAcinetobacter baumannii, a hardy, common bacterium, in American military personnel wounded in Iraq. A. baumannii carry natural drug resistance genes, in addition to developing resistance under antibiotic selective pressure. Because A. baumannii are able to survive on surfaces for up to 20 days, they pose a high risk of spread and contamination in hospitals, potentially putting immune-compromised and other patients at risk for costly and often deadly drug resistant infections. As more infected soldiers return from abroad, there is mounting concern for the possible implications for the U.S. health care system and the Veterans Affairs system in particular.
For more information please see:
Troops in Iraq Bring Resistant Bacteria Home. The New York Times, August 4, 2005
- Acinetobacter baumannii Infections Among Patients at Military Medical Facilities Treating Injured U.S. Service Members, 2002-2004. CDC Morbidity and Mortality Weekly Report November 14, 2004
APUA GAARD Report Published in CID
August 3, 2005
The 2005 Report of the Global Advisory on Antibiotic Resistance Data (GAARD), entitled"Global Antimicrobial Resistance Alerts and Implications" has been published as a supplement to Clinical Infectious Diseases, 15 August 2005, Volume 41. The report provides a uniquely comprehensive view of drug resistance patterns across the major infectious diseases by combining findings from diverse international surveillance systems run by the world's leading infectious disease experts. The document focuses on the most troubling and urgent infectious disease threats whose cures are imperiled by antimicrobial resistance: HIV/AIDS, tuberculosis, malaria, gonorrhea, pneumonia, and hospital-associated infections. See full report or learn more about the GAARD project.
FDA Bans Use of Enrofloxacin (Baytril) in Poultry!
July 28, 2005
The US Food and Drug Administration (FDA) is no longer allowing the use of the Cipro-like antimicrobial enrofloxacin for treating bacterial infections in poultry. Enrofloxacin is a fluoroquinolone antibiotic that is marketed by Bayer Corporation as Baytril. This represents the first time that the FDA has withdrawn the use of an animal drug due to concerns about emergence of antimicrobial resistance and its human health impact. Read the FDA’s Press Release and Final Decision. Also see APUA’s Ecology Program for more details.
APUA Sponsors Congressional Staff Briefing on Capitol Hill
July 19, 2005
- Antimicrobial Resistance in Hospitals: Lack of Effective Treatment for Gram Negative Bacilli and the Rise of Resistant Clostridium difficile Infections by Dale N. Gerding, MD, Chair, National and Global Public Health Committee, Infectious Diseases Society of America
- Antibiotic Resistance: Strategic Solutions by Gordon W. Grundy, MD, Regional Medical Director - Northeast Region - Aetna Inc.
- Save Antibiotic Strength Health Plans Address the Challenge of Antibiotic Resistance by Robert Scalettar, MD, Chair of the Coalition for Affordable Quality Health Care Save Antibiotics Strength Initiative
Release of Antibiotic Policies: Theory and Practice, edited by Ian Gould and J.W. van der Meer. Preface written by Stuart Levy and a chapter on Antibiotic Policies in the Developing World written by Anibal Sosa.
See excerpt from the book.
2003 Annual Leadership Award Reception
Sept 15, 2003
The Alliance for the Prudent Use of Antibiotics (APUA) honored McDonald's Corporation and scientists at the Danish Veterinary Institute at its 2003 Annual Leadership Award Reception, held at the 43rd International Conference on Antimicrobial Agents and Chemotherapy in Chicago.
See the complete press release.
July 14, 2003
By Valerie Reitman, LA Times Staff Writer
McDonald's decision to remove antibiotics from meat products could be an effective weapon in the fight to prevent drug resistance. For nearly half a century, farmers have been feeding poultry and some livestock the same antibiotics - penicillin, tetracycline, bacitracin - used to treat sick human beings. See the complete article.
SARS --Severe Acute Respiratory Syndrome
The recent epidemic of Severe Acute Respiratory Syndrome, or SARS, underscores the increasingly global nature of infectious disease and the need for international public health vigilance. Having emerged in November 2002 in southern China's Guangdong province, the deadly illness has since spread to Asia, Europe, and North America.
For current information on SARS: U.S. Centers for Disease Control and Prevention
World Health Organization
Department of Health, Hong Kong SAR, China
Ministry of Health, Singapore
New Wave of Community MRSA in Boston and in San Francisco Alarms Doctors.
March 5th, 2003
APUA is concerned to see the recent reports of methicillin resistant Staph aureus (MRSA) appearing in patients in communities and in community hospitals in Los Angeles, San Francisco, and Boston. This finding is further evidence of the emergence and threat of a critically important resistance problem in the community which was previously primarily faced in tertiary care settings. Clearly, the misuse and overuse of antibiotics in the community is the major contributing force. APUA through its GAARD and ROAR programs, aims to find ways to identify an incipient resistance problem before it occurs and to recommend appropriate interventions to prevent the resistance problem from emerging and spreading in the community. For now, we must continue to encourage the prudent use of antibiotics for common bacterially-caused illnesses. See the San Francisco Chronicle article
FDA issues Final Rule on Labeling Requirements for Systemic Antibacterial Drug Products Intended for Human Use.
February 5, 2003
Second confirmed case of Vancomycin-resistant S. aureus in the US
October 11, 2002
see the CDC report.
Curb farm antibiotics
August 29, 2002
Panel recommends restricting drugs used on livestock as fears of risk to humans increase See the full article
Experts Issue Report to Health Canada on Use of Antimicrobials in Food Animals June, 2002
An Advisory Committee, represented by a wide range of experts and stakeholders submitted its consensus report, Uses of Antimicrobials in Food Animals in Canada:
Impact on Resistance and Human Health, to Canada in June 2002.
The Report was made available to the public in September. The Committee made 38 recommendations for actions by public health officials, veterinary professional organizations or industry to better protect the health and interests of Canadians.
Vancomycin-resistant S. aureus in the US
July 5, 2002
In 1996, the first case of reduced susceptibility of Staphylococcus aureus to vancomycin was reported in Japan. In July 2002, the CDC reported the first case of vancomycin-resistant S. aureus in the US (vancomycin MIC >32 µg/mL). The CDC cautions that "The emergence of VRSA underscores the need for programs to prevent the spread of antimicrobial-resistant microorganisms and control the use of anti-microbial drugs in health-care settings." See the CDC report.
Decline in antibiotic prescribing reported
June 19, 2002
Antibiotic prescriptions for children have decreased dramatically in the US over eleven years. A survey conducted by the CDC of office-based physicians shows that antibiotic prescriptions for children under 15 years-old decreased from 46 million to 30 million from 1989 to 2000. The number of visits to physicians' offices remained constant during that time. The study found specific declines in prescriptions for pharyngitis and upper respiratory tract infection; however, prescribing rates for sinusitis did not change. The original study is published in JAMA 2002, 287:3096-3102. See also the CDC press releaseand an article in the Washington Post.
Strep throat bacteria show resistance to antibiotics
April 17, 2002
A recent study from the U.S. reports an outbreak of Group A Streptococci (GAS) that are resistant to erythromycin, an antibiotic commonly used to treat strep throat. GAS are the most common cause of strep throat, a disease that can lead to rheumatic fever in a small percentage of patients. In a study reported in the New England Journal of Medicine, 48% of throat cultures from schoolchildren containing GAS were resistant to erythromycin.
Alerted by this unusual outbreak in the school in Pittsburgh, PA, the researchers gathered similar data from the surrounding Pittsburgh community. Of 100 throat cultures containing GAS, 38% of them were resistant to erythromycin. This study suggests that erythromycin-resistant strep throat infections may be more widespread than is commonly acknowledged. The original study was published in NEJM 2002 Vol 346, No 16, pgs 1200-1206.
Pharmacy at U. Pennsylvania Restricts Antibiotic Sales
October 16, 2001
In response to the ongoing stockpiling of antibiotics, the pharmacy at the Hospital of the University of Pennsylvania is restricting sales of ciprofloxacin, levofloxacin, doxycycline and amoxicillin in the outpatient pharmacy. All prescriptions for these agents must include an indication to justify use. Only a 10-day supply of antibiotics will be dispensed; however, proven infections requiring longer courses of therapy will be handled on an individual basis. Prescriptions for personal stockpiles will not be filled. The University of Pennsylvania adopted this policy to be proactive, to prevent depletion of existing stores of antibiotics, and to reduce the sense of paranoia and alarm concerning the hospital's antibiotic supply.
This action by the pharmacy at the Univ. of Pennsylvania is in keeping with therecommendations of Dr. Stuart Levy, President of APUA, that third party payers and pharmacists should not dispense ciprofloxacin or other antibiotics without a specific indication for their use.
WHO Global Strategy September, 2001
To combat the growing threat of antimicrobial resistance, the World Health Organization (WHO) released its first Global Strategy for Containment of Antimicrobial Resistance. APUA developed one of the technical documents supporting the WHO Global Strategy,Antibiotic resistance: synthesis of recommendations by expert policy groups.
AMA Recommends Restricting Antibiotic Use in Animals June 2001
The policy making group of the American Medical Association (AMA) adopted a resolution at its 2001 annual meeting opposing the sub therapeutic uses of antimicrobials in animal agriculture and called for regulations to support this stance. The AMA resolution says that almost 80% of antimicrobial use in agriculture is for growth promotion, as pesticides, or prophylactic (disease prevention). The resolution notes that this prolonged low-level use of antimicrobials is likely to promote the development of resistance. The resolution states that the increase of antimicrobial resistance is a threat to human health.
The Animal Health Institute (AHI) responded with a statement saying that the AMA's resolution was too sweeping and was "an ineffective solution to addressing antibiotic resistance." In particular, the AHI says that there is little scientific evidence indicating a transfer of antibiotic resistance from animals to humans. The AHI advocates additional efforts into research and monitoring antimicrobial resistance.
The Antibiotic Resistance Act of 2001 May 15, 2001
On May 9, Rep. Sherrod Brown, (D. Ohio) introduced HR 1771, the Antibiotic Resistance Act of 2001. (The version appended here is the one that was introduced, despite its not having a bill number nor cosponsors listed on the bill.)
This bill seeks funding for the Department of Health and Human Services (DHHS) to implement the priority items in the Federal Government's Interagency Action Plan, adopted in January 2001. The bill pertains only to DHHS agencies. The bill begins with a list of findings and then includes the priority action items.
Rep. Brown is the Ranking Minority Member of the House Energy and Commerce Committee's Subcommittee on Health. The Chairman of the Subcommittee, Rep. Bilikraus, (R. Florida), joined in support of the bill.
At a press conference announcing the bill, Rep. Brown was joined by other Members of Congress -- Rep. Slaughter (NY)(a microbiologist), Rep. Waxman (CA) (former chair of House Committee on Energy and Commerce), Rep. Ganske (Iowa)(a physician), Rep. Pallone, and Rep. Greene.
Other cosponsors of the bill included: Rep. John Dingel, Ranking Member, Energy and Commerce (Michigan), Rep. DeGette (Colorado), Rep. Jones (Ohio), Rep. Kildee (Michigan), Rep. Towns (NY), Rep. Lee (California), Rep. Filner (CA), Rep. Capuano (MA), and Rep. Kucinich (Ohio).
Last year the Science Committee in the House expressed interest in holding hearings on antibiotic resistance and one possibility is that this Committee might hold a hearing on this bill sometime during the summer.
If you have questions on the bill, please contact Earl Seeley, staff to Rep. Brown, orBarbara Souder at APUA.
Five Patients Show Resistance to Linezolid, a Novel Antibiotic April, 2001
As the first structurally different antibiotic introduced in almost 3 decades, Linezolid held, and still holds, great promise as a powerful new drug for treating difficult infections. However, the emergence of resistance to this new antibiotic in 5 patients, recently reported in The Lancet (vol. 354:1179 April 14, 2001), undermines confidence in its continued efficacy. All five patients received the drug for prolonged periods of time (21-40 days). The findings again demonstrate that long-term use of a single antibiotic increases the chance for emergence of strains bearing resistance. A major lesson is that any new antibiotic can quickly become ineffective due to resistance in patients undergoing chronic long-term use. New classes of antibiotics are needed to fight these resistant infections.
US Interagency Action Plan Jan. 18, 2001
The US Department of Health and Human Services released its Interagency Action Plan for fighting antimicrobial resistance. The Action Plan sets priorities and deadlines for ten US agencies and departments in the following areas: 1) surveillance, 2) prevention and control, 3) research, and 4) product development. These four areas contain 84 action items, including 13 priority action steps considered essential to addressing antimicrobial resistance. Of these 13 priorities, seven are already underway, and six are planned to begin within the next one to two years.