APUA-Belarus was established in 2000 by members of the Department of Infectious Diseases from Vitabesk Medical University. The founding of the chapter was assisted by APUA-Russia. The chapter coordinated an international conference called "The problems of rational application of antibiotics" featuring speakers from Italy, Russia and Belarus. The conference was held in Vitabesk on October 12-13, 2000; partial funding for the conference came from the APUA small grants program.
An APUA small grant funded a study to correlate the use of antibiotics for the treatment of acute intestinal infections to resistance patterns among Salmonella and Shigella organisms. APUA-Belarus is also involved in national antibiotic surveillance in patients with acute intestinal infections.